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This transgene consists of the full-length adult mouse (BALB/c) ventricular isoform of Myl2 (regulatory myosin light chain 2) with serines 14, 15, and 19 each mutated and replaced by alanine, under the control of the murine alpha-myosin heavy chain promoter. Replacing the three serines with alanines results in a nonphosphorylatable Myl2. Examination of atrial myofibrillar protein composition shows a progressive replacement of the atrial isoform with the mutated ventricular form as mice age. (J:114298)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
