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A targeting vector inserted GFP coding sequences and an frt-flanked hygromycin resistance gene into exon 1. Transient transfection with a vector encoding flp recombinase removed the hygromycin resistance gene and one of the frt sites from targeted ES cells. The expression pattern of GFP in homozygous mutant embryos and adult mice mirrors that of the endogenous gene. (J:114151)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
