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A 2.3 kb fragment of the Valpha gene, containing 2 kb of 5' flanking sequence was fused to a 195 bp cDNA fragment covering the unique V-J junction, with the remaining nucleotides of the Jalpha region plus ~100 bp of JC intron sequence. This VJ segment was inserted upstream of a 9.8 kb Calpha clone containing all the Calpha exons and extending .5 kb downstream of the polyA signal. A 683-bp fragment containing the immunoglobulin heavy-chain enhancer (EH) was inserted at the junction between the VJ and Calpha segments. (J:69570)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
