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A targeting vetor was used to replace the JH1 and JH2 elements with the D23stop joint. A floxed neo included in the vector was subsequently removed by transient transfection of cre recombinase. A second targeting vector was then used to introduce a double loxP site and frt-flanked neo into the VH81x position. Crossing these mice with cre deleter mice results in the loss of the DH elements and the insertion of a D23stop VDJ cassette. (J:113434)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
