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The two exons encompassing the HIT domain were deleted using cre mediated recombination. The deletion resulted in a frame-shift that caused the loss of the C-terminal 181 amino acids including the histidine triad and zinc finger domains. The mutant transcript was found to be expressed in various tissues, including brain, by Northern blot analysis. (J:113297)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
