Exons 8 and 9 were flanked by loxP sites and a neo resistance cassette with a loxP site was inserted downstream of the floxed exons via homologous recombination. The neo cassette was removed by mating with CMV-Cre transgenic mice. (J:111787)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count