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Exon 1, including the initiation codon, was replaced with a reporter construct containing a lacZ gene, stop codon and poly(A) signal. RNA transcripts were quantified in various tissues using RT-PCR to confirm gene ablation. Beta-galactosidase expression is observed in the vasculature of all major organ systems tested. Some ectopic expression is also noted. (J:111715, J:199685)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
