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A targeting vector was designed to insert the human IGKC and a neo cassette such that the sequence containing a splice signal and 12 base pairs of endogenous sequence were replaced. The remainder of the locus was rendered nonfunctional. Flow cytometry demonstrated the expression of humanized proteins on B cell surfaces. (J:113008)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
