A targeting vector was designed to replace exons 3-5 with a cassette containing the EN2 intronic sequences, a splice acceptor site, an IRES-lacZ and a neo cassette with a polyA signal. Western blot failed to detect protein in mutant liver samples. (J:112807)
Basic Information
Disruption caused by insertion of vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count