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A targeting vector was designed to inactivate the locus by inserting an IRES-betagal-MC1-neo into exon 1. Expression of the betagal would have been under the control of the endogenous promoter, however, no expression was detected. RT-PCR failed to detect wild-type transcripts resulting from exon 1. Protein analysis failed to detect immunoreactivity in mutants. (J:111359)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
