A Beta-geo gene trap vector, pGT1Lxf, was inserted into intron 13 of the locus. The first 285 amino acids were fused to the Beta-galactosidase-neomycin protein. This allele retains most of the proline-rich stretch as it loses only the C-terminal 103 residues. Western blots demonstrate expression of chimeric protein composed of the endogenous N-terminal polypeptide fused to Beta-geo. (J:111801)
Basic Information
Insertion of gene trap vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count