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ES cells from Ighg1tm1(IRES-cre)Cgn heterozygous mice were targeted at the ROSA26 locus with a conditional transgene encoding a constitutively active form of the STAT-3 protein proceded by a floxed STOP cassette and followed by an IRES-EGFP cassette. Upon SRBC immunization, STAT-3c expression is detected in the majority of germinal centers and IgG1 memory B cells by EGFP expression. (J:109583)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
