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A targeting vector was designed to replace the two exons encoding the TIR domain with a neomycin resistance gene. The insertion created a stop codon in the N-terminal portion of the locus. Immunoblot confirmed that disruption of the locus abolished the expression of protein. (J:111205)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
