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The 3' end was modified to flank exons 9 and 10 wit loxP sites, insert a mutated duplication of exons 9 and 10 downstream of all alpha1 coding and regulatory sequences and insert a neo cassette flanked by frt sites. Exons 9 and 10 were fused together and intron 9 deleted in the vector. The knockin mutations for exon 9 were to change serine 270 to histidine and leucine 277 to alanine. The neo was subsequently removed via crossing with FLPe general deleter mice. (J:110982)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
