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A targeting vector was designed to incorporate a 3-way stop codon at the 5' end of exon 21 and a neo cassette upstream of exon 21 that was subsequently removed via cre mediated recombination. Mutants demonstrated that the unique sequence of Nup96 was abolished and exon 20, which encodes the 6 kDa polypeptide shared by Nup98 and Nup96, was maintained so that expression of Nup98 remained uninterrupted. (J:110907)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
