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A targeting vector was designed with 3 loxP sites such that exon 5 and a PGK-neo could either both or either be removed from the locus by cre expression. Removal of exon 5 would result in a frame shift that would putatively produce a nonfunctional 244 amino acid product with a molecular weight of 26.8 kDa instead of the ~130 kDa wild-type protein.
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
