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A targeting vector was designed to mutate the KI-KII element (Rr163) such that 8 and 9 bp were replaced, respectively. The sequence of KI was mutated from TCCACGCATGCTTGGA to TGTACGCTGCTGATGA and KII was mutated from TCCTCTTCAGTGAGGAG to AGCTCTTCTAGACTGA. LoxP sites were inserted to surround 4 kb encompassing the promoter of the long J-C K germline transcript, located immediately upstream of the KI-KII element. This sequence was deleted through subsequent cre-mediated recombination. (J:110775)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
