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A targeting vector was designed such that the codons of the five C-terminal amino acids, VWRPY, were changed to the stop codon UAG and to codons encoding substituted amino acids designed to create a new NotI site. A loxP-flanked neo was included in intron 5 and was subsequently removed via cre-mediated excision. RT-PCR and Western blot analyses demonstrated expression of the mutant transcript and protein, respectively. (J:109584)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
