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A 69 bp fragment containing an AU rich element was inserted into the 3' untranslated region downstream of the stop codon via homologous recombination. In addition a self-excising neo resistance cassette consisting of a floxed mouse testes-specific Ace promoter fused to the cre recombinase and neomycin resistance genes was also inserted and then removed during germline transmission. RT-PCR showed that message levels are reduced about 40 - 50% in adipose tissue, liver, kidney, and heart in homozygotes compared to wild-type mice. Mice generated from one targeted ES cell clone (YTC-1) also have a tightly linked mutation Atp2b2m1Mae. (J:110607)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
