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The transgene comprises a 6.4-kb fragment containing a B*3501 allele of the human major histocompatibility complex, class I, B antigen gene. Surface expression of the transgene product on peripheral blood lymphocytes and spleen cells was demonstrated by flow cytometry with an anti-HLA Class I monoclonal antibody; expression levels were similar to those of endogenous mouse MHC antigens. Western blot analysis revealed high levels of expression in lung, spleen, thymus and skin and low to medium expression in heart and brain. (J:110794)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
