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A floxed Dicer1 allele was created in a stem cell line (4E4) which contained a null Dicer1 allele, Dicer1tm1Ghan. A Dicer1 allele with exons 22 and 23 flanked by loxP sites replaced the remaining wild-type Dicer1 allele in the ES cells. The resulting ES cells were used to create conditional mice homozygous for the floxed Dicer1 allele. (J:101186)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
