Exon 7 was flanked by loxP sites after removal of a FRT-flanked PGK-neo cassette. Cre-mediated deletion of exon 7 will result in a +2 frameshift in the transcriptional reading frame causing premature termination of transcription. (J:110469)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count