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Targeting constructs for the Hoxc-4 and Hoxc-13 genes were used to put loxP sites into a targeting vector. After electroporation of CCE ES cells with the targeting vector, homologous recombination produced doubly-targeted ES cells. Following introduction of a Cre expressing plasmid, deletion of 130 kb encompassing the Hoxc gene cluster resulted. (J:61710)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
