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The transgene contains the cDNA encoding human myeloid cell leukemia sequence 1 (BCL2-related) joined to the promoter and 5' regulatory sequences of the human eukaryotic translation elongation factor 1 gene, including 1.5 kb of 5' flanking DNA, the first (noncoding) exon and the first intron. RT-PCR analysis detected expression in all organs/tissues examined; levels of expression differed among organs, being greatest in the islets of Langerhans, but was much lower everywhere than that of the endogenous gene. Levels in all tissues were too low for detection by northern blot analysis. (J:83768)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
