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A targeting vector was designed to contain a 159-nt long human MYC sequence encoding the carboxy terminal part of the protein for insertion in place of the corresponding mouse sequence. The vector contained a neomycin resistance cassette with an RNA polymerase II promoter but without a polyA sequence immediately downstream of the MYC stop codon. The 3' UTR of the endogenous myc, including runs of Us, AREs and the two polyA sites was deleted and replaced by late SV40 3' UTR including a polyA site. (J:70610)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
