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In an ES cell line in which a loxP site previously had been inserted into the Hira gene by homologous recombination, a second loxP site was inserted into the genome between the Gp1bb and Cldn5 genes using a retrovirus. Transient cre-expression in the ES cells resulted in deletion of a 150-kb region from Cldn5 to Hira. (J:110378)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
