The human GPHB5 open reading frame was inserted into a vector containing the metallothionein-1 promoter and a consensus translation initiation sequence was placed upstream of the GPHB5 ATG. Introns from the rat INS2 and a human GH polyadenlyation signal sequence were cloned 5' and 3' of GPHB5 to enhance transcription. (J:105176)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count