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This transgene contains a constitutively active mouse Akt1, in which critical residues (T308D/S473D) for activation of Akt1 are replaced by negatively charged amino acids, under the control of the mouse alpha-myosin heavy chain. There is about 400 times more transgene product than endogenous Akt1 in cardiac tissue. (J:75780)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
