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EN
The randomly integrating (within a gene) gene trap vector pU18 contains 1.8 kb of intron 1 and part of exon 2, including the splice acceptor, from the mouse engrailed 2 gene (En2) followed by an internal ribosome entry site (IRES) and the Betageo beta-galactosidase/neomycin resistance fusion gene with a mammalian polyadenylation signal. Three stop codons occur in the exon sequence upstream of and in frame with the Betageo translation initiation codon. Mutant and wild-type loxP sites used for 5' RACE analysis and for in vitro exchange of other sequences for Betageo are present. (J:109358, J:110088)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
