A 2.3 kb genomic fragment containing all three coding exons, 840 bp of the putative promoter and 100 bp 3' relative to the termination codon was deleted and replaced with a hygromycin selection cassette, loxP site and a promoterless puromycin resistance gene. RT-PCR analysis confirmed that no detectable transcript was expressed from this allele. (J:50872)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
STOCK 129/Sv and C57BL/6J and SJL
Targeted
Insertion, Intragenic deletion
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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