This transgene consists of the mouse alpha myosin heavy chain (Myh6) promoter driving the expression of the human IGF1R cDNA in the heart. IGF1R ligand binding assays indicate that line 7 shows a 20-fold increase in expression of IGF1R in cardiac membrane fractions. (J:87944)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count