A neomycin resistance cassette replaced the first exon including the translational start codon and the lipase consensus sequence motif (GXSXG). Northern analysis of white adipose tissue did not detect transcript in white adipose tissue from homozygous mutant mice. Similarly, western blot analysis of white adipose tissue from homozygous mutant mice did not detect protein. (J:108546)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd-Hprt1b-m3
Targeted
Insertion, Intragenic deletion
--
1
2
59

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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