A vector was designed to replace the 455-residue protein-coding region containing the pro-metalloprotease, disintegrin, and cysteine-rich domains at positions 79-533 with a neomycin resistance gene. Absense of transcript was confirmed in Northern blot of mutant testis. Also, protein extracts from testicular germ cells lacked a 120-kDa protein corresponding to the precursor form of Adam1b protein. (J:109221)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
Insertion, Intragenic deletion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
Wechat
Comparison
Al agent
Tutorials
Back to top