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An A to T base change was introduced into exon 8 which caused the substitution of tyrosine, residue 385, with phenylalanine (Y385F). Numbering is based on numbering for the sheep protein. The actual mouse modification is Y371F. A floxed neomycin resistance cassette was introduced in intron 9. The cyclooxygenase function was inactivated but not the peroxidase function. (J:109548)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
