A gene trap vector containing a splice acceptor sequence, an internal ribosomal entry site, a selectable colorimetric marker, beta-geo and a polyA sequence was inserted into intron 13 of the locus. RT-PCR confirmed the expression of a fusion transcript in mutant brains, however, the level of expression was significantly lower than in wild-type mice. (J:108880)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S5/SvEvBrd
Gene trapped
Insertion of gene trap vector
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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