A targeting vector was designed to delete exons 9-11, which encode the core of the kinase domain and are common to almost all known transcripts from the locus. A frame shift was introduced into the locus, generating multiple stop codons downstream of exon 9. (J:105301)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count