Exon 1 and the promoter region were flanked with loxP sites by homologous recombination. The FRT-flanked neomycin cassette inserted downstream of the 3' loxP site was removed by Flp mediated recombination. Protein expression is similar to wild-type. (J:108369)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count