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A 9.2kb transgene containing the human IGFBP1 cDNA under the control of the mouse alpha-fetoprotein regulatory sequence was microinjected into the pronuclei of C57BL/6 x CBA F1 embryos. Four founder lines were established (2,3,4,16). Line 16 contains 8 copies of the transgene and expresses at high levels in fetal liver and yolk sac with lower levels of expression in gut epithelial cells and brain glial cells. (J:108414)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
