A targeting vector was designed to flank exons 4 and 5 with loxP sites. Deletion of these exons would cause a frame shift, resulting in a stop codon after eight missense amino acids in exon 6. (J:107615)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count