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A targeting vector was designed to replace exons 25-27, encoding the PARP domain, with a neomycin resistance cassette. The vector was designed using the exon nomenclature in J:71663. This allele was expected to produce a null, however, truncated proteins were expressed from the locus that lacked the catalyitic PARP domain. Smaller proteins putatively contain the ANK and SAM domains and larger proteins are probably variants splicing the truncated protein to the downstream neo. (J:106917)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
