Log In|Sign Up
EN
The transgene constructs encode a T cell receptor (TCR) that recognizes the Ld class I major histocompatibility complex (MHC) antigen SIYRYYGL peptide in the context of the H2b MHC class I molecule. Rearranged genomic cosmids containing the entire Tcra and Tcrb coding and promoter regions from the cytotoxic T cell clone 2C were isolated and coinjected into fertilized eggs. Transgenic H2b mice have large numbers of T cells in the periphery that express the transgenic TCR. In the periphery of transgenic H2d mice, T cells expressing the transgenic TCR are deleted. (J:107523, J:120081)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
