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The transgene contains a truncated human TGFBR2 gene under the control of the human MT2A promoter. The truncated receptor contains the extracellular, transmembrane, and juxtamembrane domains. Most of the cytoplasmic domain including the kinase domain is deleted. This mutant receptor acts as a dominant-negative mutation. The promoter contains four metal responsive elements and a beta-globin TATA element, splice sites, and polyadenylation signal. This record represents pooled data or data where the line number is not specified. (J:44579)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
