A cassette containing a tetracycline-controlled transactivator (tTA), and a tetracycline responsive element (TRE) was inserted upstream of the translation start site in exon 2. Blm expression in mutants was present in the absence of dox. Upon administration of dox, expression was reduced, however, leaky expression was found in all tissues examined. (J:106458, J:107374)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
Insertion
--
1
3
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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