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A targeting vector was designed to delete the last 150 nucleotides of exon 11 and all of intron 11. The deletion created an in-frame fusion between codon 608 in exon 11 and codon 659 in exon 12. A floxed neo included in the vector was removed via cre-mediated recombination. Northern and Western blot demonstrated that no lamin A was produced. Lamin C was produced at wild-type levels. (J:106473)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
