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LoxP sites flank the coding region of Gja1 and a frt-flanked neomycin resistance cassette that immediately follows the termination codon. The coding region and 88 bp of downstream sequence from Gja3 have been inserted between the Gja1 termination codon and its downstream DNA so that Cre recombinase mediated recombination will delete the Gja1 coding sequence and place that of Gja3 under control of Gja1 regulatory sequences. The GJA1 protein level is slightly elevated in heart, but is not altered in brain, of mice heterozygous or homozygous for the present allele. As in wild-type mice, the GJA3 protein is not expressed in brain or heart. (J:106509)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
