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The transgene comprises a 2.2 kb 5' flanking fragment containing the promoter and upstream regulatory elements of the human glial fibrillary acidic protein gene joined to a 912 bp DNA fragment encoding human CDK4 followed by a 0.5 kb fragment containing an intron and the polyadenylation signal from the mouse protamine 1 gene. RT-PCR demonstrated expression of mRNA and western blot analysis of protein in astrocytes. (J:86020)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
