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This transgene consists of the mouse alpha myosin heavy chain (Myh6) promoter and the inter-Src homology 2 (iSH2) domain of Pik3r1 (p85) fused to the N-terminus of bovine PIK3CA (p110alpha). Myh6 drives the expression of a constitutively active phosphatidylinositol 3-kinase specifically in cardiac myocytes. Immunoprecipitation and western blotting confirmed transgene expression exclusively in the heart and a lipid kinase assay indicated that phosphatidylinositol 3-kinase activity was increased 6.5-fold. (J:62707)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
