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This transgene consists of the Thy1 promoter followed by a loxP flanked stop signal and a truncated form of the murine Ntrk2 gene fused to EGFP. The truncated cDNA for Ntrk2 includes the region encoding amino acids 1-477 plus 74 bp of the 5' UTR. Cre mediated recombination removes the stop and allows expression of the fusion protein which functions as a dominant negative receptor. Seven founders were created however data for line 817 only were shown. (J:105706)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
