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A floxed neomycin cassette was inserted between exons 2 and 3 and a third loxP site was inserted upstream of exon 2. The neomycin cassette was subsequently removed from properly targeted ES cells by transient transfection with a cre expressing vector. As a result, exon 2 was flanked by loxP sites. The resulting mice were crossed with mice carrying Tg(CMV-cre)1Cgn which caused the germline excision of exon 2. (J:105917)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
