A targeting vector was designed to insert loxP sites around exon 4. A neomycin and a spectinomycin cassette with an additional loxP site were inserted into intron 4. Deletion of exon 4 would cause a frame shift, resulting in a premature stop codon. (J:105458)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count